Chiral 2-Aryl Ferrocene Carboxylic Acids for the Catalytic Asymmetric C(sp³)–H Activation of Thioamides

• Sekine, Daichi

• Ikeda, Kazuki

• Fukagawa, Seiya

• Kojima, Masahiro

• Yoshino, Tatsuhiko

• Matsunaga, Shigeki

書誌事項

タイトル別名

• Chiral 2-Aryl Ferrocene Carboxylic Acids for the Catalytic Asymmetric C(sp(3))-H Activation of Thioamides

抄録

Enantioselective C-H functionalization reactions using trivalent group 9 metals (Co, Rh, Ir) have been investigated mainly on the basis of the development of well-designed chiral cyclopentadienyl (Cp) ligands. Although it has recently been demonstrated that chiral carboxylic acids combined with achiral Cp-type ligands can enable highly enantioselective C-H functionalization reactions, the structural diversity of the applied chiral acids remains limited. Here, we report that chiral 2-aryl ferrocene carboxylic acids, which are easily obtained from diastereoselective ortho lithiation and Suzuki-Miyaura coupling, can serve as external chiral sources for the Cp*Co-III-catalyzed enantioselective C(sp(3))-H amidation of alpha-aryl thioamides using dioxazolones.

収録刊行物

• Organometallics

  Organometallics 38 (20), 3921-3926, 2019-10-28

  American Chemical Society

詳細情報

• CRID: 1051412328385781760
• NII論文ID: 120006895040
• DOI: 10.1021/acs.organomet.9b00407
• ISSN: 15206041
• ISSN: 02767333
• HANDLE: 2115/79616
• Web Site: https://pubs.acs.org/doi/pdf/10.1021/acs.organomet.9b00407
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN