Molecular cloning of medaka orexin and orexin receptor and decreased spontaneous movement in response to an orexin inhibitor

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  • Niisawa Tomoyuki
    Department of Pharmacology, Hirosaki University, Graduate School of Medicine
  • Naruta Naoki
    Department of Pharmacology, Hirosaki University, Graduate School of Medicine
  • Murakami Agnieszka M.
    Department of Pharmacology, Hirosaki University, Graduate School of Medicine
  • Yonekura Manabu
    Department of Cardiology and Nephrology, Hirosaki University, Graduate School of Medicine
  • Hirota Kazuyoshi
    Department of Anesthesiology, Hirosaki University, Graduate School of Medicine
  • Itagaki Shirou
    Collaboration Center for Community and Industry, Sapporo Medical University
  • Murakami Manabu
    Department of Pharmacology, Hirosaki University, Graduate School of Medicine

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抄録

Orexin （hypocretin） is a neuropeptide secreted by hypothalamic neurons that is activated during motivating behaviors and active waking. Our knowledge of orexin is mainly limited to mammalian species, such as humans, mice, and rats. In the present study, we cloned orexin and its receptor from the medaka brain. Additionally, we analyzed the effect of an orexin inhibitor （SB-649868） on spontaneous behavior. The orexin inhibitor decreased spontaneous movement of the fish, suggesting the importance of the orexin system in spontaneous movement. Our results indicate that medaka might be a suitable animal model for neurological behavioral studies.

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  • 弘前医学

    弘前医学 71 (1), 55-64, 2020

    弘前大学大学院医学研究科・弘前医学会

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