Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats

• Yukimatsu, Nao

• Gi, Min

• Okuno, Takahiro

• Fujioka, Masaki

• Suzuki, Shugo

• Kakehashi, Anna

• Yanagiba, Yukie

• Suda, Megumi

• Koda, Shigeki

• Nakatani, Tatsuya

• Wanibuchi, Hideki

抄録

Recent epidemiological studies have indicated that occupational exposure to the aromatic amine acetoaceto-o-toluidide (AAOT) was associated with a marked increase in urinary bladder cancers in Japan. However, little is known about the carcinogenicity of AAOT. To evaluate the urinary bladder carcinogenicity of AAOT, male and female F344 rats were treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 weeks followed by dietary administration of 0, 0.167, 0.5, or 1.5% AAOT for 31 weeks....

収録刊行物

• Archives of Toxicology

  Archives of Toxicology 93 (12), 3617-3631, 2019-10-31

  Springer

キーワード

• AAOT
• OTD
• bladder carcinogenicity
• rat
• occupational urinary bladder cancer

詳細情報

• CRID: 1050849378481985408
• NII論文ID: 120006900913
• NII書誌ID: AA11617824
• ISSN: 14320738
• ISSN: 03405761
• DOI: 10.1007/s00204-019-02605-4
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_14320738-93-12-3617
• Web Site: http://link.springer.com/content/pdf/10.1007/s00204-019-02605-4.pdf
• Web Site: http://link.springer.com/article/10.1007/s00204-019-02605-4/fulltext.html
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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