Promotion effects of acetoaceto-o-toluidide on N-butyl-N-(4-hydroxybutyl)nitrosamine-induced bladder carcinogenesis in rats

• Yukimatsu, Nao

• Gi, Min

• Okuno, Takahiro

• Fujioka, Masaki

• Suzuki, Shugo

• Kakehashi, Anna

• Yanagiba, Yukie

• Suda, Megumi

• Koda, Shigeki

• Nakatani, Tatsuya

• Wanibuchi, Hideki

Abstract

Recent epidemiological studies have indicated that occupational exposure to the aromatic amine acetoaceto-o-toluidide (AAOT) was associated with a marked increase in urinary bladder cancers in Japan. However, little is known about the carcinogenicity of AAOT. To evaluate the urinary bladder carcinogenicity of AAOT, male and female F344 rats were treated with N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 4 weeks followed by dietary administration of 0, 0.167, 0.5, or 1.5% AAOT for 31 weeks....

Journal

• Archives of Toxicology

  Archives of Toxicology 93 (12), 3617-3631, 2019-10-31

  Springer

Keywords

• AAOT
• OTD
• bladder carcinogenicity
• rat
• occupational urinary bladder cancer

Details

• CRID: 1050849378481985408
• NII Article ID: 120006900913
• NII Book ID: AA11617824
• ISSN: 14320738
• ISSN: 03405761
• DOI: 10.1007/s00204-019-02605-4
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_14320738-93-12-3617
• Web Site: http://link.springer.com/content/pdf/10.1007/s00204-019-02605-4.pdf
• Web Site: http://link.springer.com/article/10.1007/s00204-019-02605-4/fulltext.html
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN