Intestinal helminth infections in HIV-infected patients in Savannakhet after establishment of an HIV registration network in Lao People’s Democratic Republic

• Kaneshiro, Yukako

• Sourinphoumy, Khamphang

• Imaizumi, Naoki

• Rasaphon, Mangkhalar

• Kuba-Miyara, Megumi

• Sakihama, Shugo

• Guerrero, Carmina Louise Hugo

• Nhativong, Ketsaphone

• Nonaka, Daisuke

• Pongvongsa, Tiengkham

• Kobayashi, Jun

• Kounnavong, Sengchanh

• Fukushima, Takuya

Abstract

Background: In Lao People’s Democratic Republic (PDR), which borders China, Vietnam, Cambodia, Thailand, and Myanmar, the number of HIV-infected patients has increased in recent years. HIV-infected patients diagnosed in Lao PDR are enrolled in a registration network and receive antiretroviral therapy (ART) covered by governmental financial support. Based on the registration network, we investigated intestinal helminth infections and coinfection with HTLV-1 in HIV-infected patients treated with an early intervention using ART in Lao PDR.\nMethods: This cross-sectional study of all 252 HIV-infected patients at Savannakhet Provincial Hospital, located in the southern part of Lao PDR, was conducted between February and March 2018. Socioepidemiological information and clinical information were collected from a registration network database and by questionnaire administered to participants. Microscopic examination of intestinal helminth infections in stool samples and particle agglutination for anti-HTLV-1 antibody in plasma were performed.\nResults: The median age of all 252 participants was 39 years old (range, 18–59). Based on the registration network database, there were 156 (61.9%) HIV-infected patients with a CD4-positive cell count ≥ 200 cells/μL and 146 (57.9%) with an HIV viral load < 250 copies/mL. Among 212 stool samples, 75 (35.4%) were found to contain one or more intestinal helminth species, including Opisthorchis viverrini (16.5%), Strongyloides stercoralis (10.8%), hookworm (10.4%), and Taenia saginata (3.3%). This rate of intestinal helminth infections was lower than that of a previous report conducted before the establishment of the registration network for HIV-infected patients in Lao PDR. There was no significant association between intestinal helminth infections and a lower CD4-positive T cell count or higher HIV viral load. HIV-infected patients with anti-HTLV-1 antibody positivity were not found in this cohort.\nConclusion: The registration network and an early intervention using ART may provide good medical care and improve the clinical course of HIV-infected patients in Lao PDR. However, the incidence of intestinal helminth infections remains high at 35.4%. The development of a specific medical care system for helminth infection for HIV-infected patients is necessary.

論文

Journal

• Tropical Medicine and Health

  Tropical Medicine and Health 47 14-, 2019-02-11

  Springer Nature

Keywords

• Human immunodeficiency virus
• Helminth infections
• Human T cell leukemia virus type I
• Registration network

Details

• CRID: 1050292726806458240
• NII Article ID: 120006937801
• ISSN: 13494147
• DOI: 10.1186/s41182-019-0142-0
• HANDLE: 20.500.12000/47230
• Web Site: https://u-ryukyu.repo.nii.ac.jp/records/2011223
• Web Site: http://link.springer.com/content/pdf/10.1186/s41182-019-0142-0.pdf
• Web Site: http://link.springer.com/article/10.1186/s41182-019-0142-0/fulltext.html
• Web Site: https://search.jamas.or.jp/link/ui/2020369335
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN