Myc controls a distinct transcriptional program in fetal thymic epithelial cells that determines thymus growth

• Cowan, Jennifer E.

• Malin, Justin

• Zhao, Yongge

• Seedhom, Mina O.

• Harly, Christelle

• Ohigashi, Izumi

• Kelly, Michael

• Takahama, Yousuke

• Yewdell, Jonathan W.

• Cam, Maggie

• Bhandoola, Avinash

抄録

Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that account for their age-specific properties, including proliferation rates, engraftability and function. Further analyses identify Myc as a regulator of fetal thymus development to support the rapid increase of thymus size during fetal life. Enforced Myc expression in TEC induces the prolonged maintenance of a fetal-specific transcriptional program, which in turn extends the growth phase of the thymus and enhances thymic output; meanwhile, inducible expression of Myc in adult TEC similarly promotes thymic growth. Mechanistically, this Myc function is associated with enhanced ribosomal biogenesis in TEC. Our study thus identifies age-specific transcriptional programs in TEC, and establishes that Myc controls thymus size.

収録刊行物

• Nature Communications

  Nature Communications 10 5498-, 2019-12-02

  Springer Nature

キーワード

• General Physics and Astronomy
• General Biochemistry, Genetics and Molecular Biology
• General Chemistry
• Multidisciplinary

詳細情報

• CRID: 1050569094143722496
• NII論文ID: 120006949467
• NII書誌ID: AA12645905
• ISSN: 20411723
• DOI: 10.1038/s41467-019-13465-y
• Web Site: http://repo.lib.tokushima-u.ac.jp/115228
• Web Site: https://www.nature.com/articles/s41467-019-13465-y.pdf
• Web Site: https://www.nature.com/articles/s41467-019-13465-y
• 本文言語コード: en
• 資料種別: journal article
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