Evaluation of dual release of stromal cell-derived factor-1 and basic fibroblast growth factor with nerve conduit for peripheral nerve regeneration: An experimental study in mice

• Shintani, Kosuke

• Uemura, Takuya

• Takamatsu, Kiyohito

• Yokoi, Takuya

• Onode, Ema

• Okada, Mitsuhiro

• Tabata, Yasuhiko

• Nakamura, Hiroaki

Abstract

Background: The development of drug delivery systems has enabled the release of multiple bioactive molecules. The efficacy of nerve conduits coated with dual controlled release of stromal cell-derived factor-1 (SDF-1) and basic fibroblast growth factor (bFGF) for peripheral nerve regeneration was investigated. / Materials and Methods: Sixty-two C57BL6 mice were used for peripheral nerve regeneration with a nerve conduit (inner diameter, 1 mm, and length, 7 mm) and an autograft. The mice were randomized into five groups based on the different repairs of nerve defects....

Journal

• MICROSURGERY

  MICROSURGERY 40 (3), 377-386, 2019-12-23

  Wiley

Details

• CRID: 1051975833339827200
• NII Article ID: 120006950815
• NII Book ID: AA11625651
• ISSN: 10982752
• Web Site: https://dlisv03.media.osaka-cu.ac.jp/il/meta_pub/G0000438repository_10982752-40-3-377
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles