転移性ホルモン感受性前立腺癌に対する アンドロゲン除去療法とアビラテロン酢酸エステル + 低用量プレドニゾロン療法の当院での初期治療経験 --複合アンドロゲン遮断療法との有効性と安全性の比較検討--

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タイトル別名
  • Comparison of Abiraterone Acetate Plus Prednisolone and Combined Androgen Blockade in High-risk Metastatic Hormone-Sensitive Prostate Cancer
  • テンイセイ ホルモン カンジュセイ ゼンリツセンガン ニ タイスル アンド ロゲン ジョキョ リョウホウ ト アビラテロン サクサン エステル+テイヨウリョウ プレドニゾロン リョウホウ ノ トウ イン デ ノ ショキ チリョウ ケイケン : フクゴウ アンド ロゲン シャダン リョウホウ ト ノ ユウコウセイ ト アンゼンセイ ノ ヒカク ケントウ

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抄録

Abiraterone acetate plus prednisone/prednisolone (AAP) and androgen deprivation therapy (ADT) was approved for the treatment of high-risk metastatic hormone-sensitive prostate cancer (mHSPC) in Japan in 2018. We investigated 22 patients with mHSPC showing ≥2 of 3 high-risk factors (Gleason score ≥8, ≥3 bone lesions or measurable visceral metastases) who received AAP plus ADT at our hospital between March 2018 and October 2019. We compared outcomes between the propensity-score matched AAP plus ADT group and the combined androgen blockade (CAB) group (19 matched pairs, 38 patients) to evaluate the efficacy and safety of AAP plus ADT. Prostate-specific antigen progression-free survival (PSA-PFS) was significantly longer in the AAP group than in the CAB group (not reached vs 15.1 months, p=0.014). Time to achievement of serum PSA ≤0.2 ng/ml and ≤0.1 ng/ml was shorter in the AAP group than in the CAB group (6.4 months vs not reached, p=0.001 and 11.0 months vs not reached, p=0.004, respectively). Although no significant intergroup difference was observed in the overall survival rates and PSA-PFS2 (PSAPFS on subsequent anticancer therapy) owing to the shorter follow-up in the AAP group, our data suggest that the clinical efficacy of AAP is betterthan that of CAB in patients with mHSPC.

収録刊行物

  • 泌尿器科紀要

    泌尿器科紀要 66 (12), 427-432, 2020-12-31

    泌尿器科紀要刊行会

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