Collapse of a lipid-coated nanobubble and subsequent liposome formation

• Koshiyama, Kenichiro

• Wada, Shigeo

Abstract

We investigate the collapse of a lipid-coated nanobubble and subsequent formation of a lipid vesicle by coarse grained molecular dynamics simulations. A spherical nanobubble coated with a phospholipid monolayer in water is a model of an aqueous dispersion of phospholipids under negative pressure during sonication. When subjected to a positive pressure, the bubble shape deforms into an irregular spherical shape and the monolayer starts to buckle and fold locally. The local folds grow rapidly in multiple directions and forming a discoidal membrane with folds of various amplitudes. Folds of small amplitude disappear in due course and the membrane develops into a unilamellar vesicle via a bowl shape. Folds with large amplitude develop into a bowl shape and a multivesicular shape forms. The membrane shape due to bubble collapse can be an important factor governing the vesicular shape during sonication.

Journal

• Scientific Reports

  Scientific Reports 6 28164-, 2016-06-16

  Springer Nature

Keywords

• Multidisciplinary

Details

• CRID: 1050569094120008832
• NII Article ID: 120006952368
• ISSN: 20452322
• DOI: 10.1038/srep28164
• Web Site: http://repo.lib.tokushima-u.ac.jp/115230
• Web Site: https://www.nature.com/articles/srep28164.pdf
• Web Site: https://www.nature.com/articles/srep28164
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN