Metabolic alterations in plasma after laparoscopic sleeve gastrectomy

• Yoshida, Naofumi

• Kitahama, Seiichi

• 山下, 智也

• Hirono, Yasuko

• Tabata, Tokiko

• Saito, Yoshihiro

• Shinohara, Ryohei

• Nakashima, Hitomi

• Emoto, Takuo

• 廣田, 勇士

• Takahashi, Tetsuya

• 小川, 渉

• 平田, 健一

抄録

Laparoscopic sleeve gastrectomy (LSG) is an important therapeutic option for morbidly obese patients. Although LSG promotes sufficient weight loss, how LSG changes plasma metabolites remains unclear. We assessed changes in plasma metabolite levels after LSG. We collected plasma samples from 15 morbidly obese Japanese patients before and 3 months after LSG. A total of 48 metabolites were quantified using capillary electrophoresis time-of-flight mass spectrometry-based metabolomic profiling. Branched chain amino acids, several essential amino acids, choline, 2-hydroxybutyric acid, 2-oxoisovaleric acid and hypoxanthine were significantly decreased after LSG. Tricarboxylic acid cycle metabolites, including citric acid, succinic acid and malic acid, were significantly elevated after LSG. This is the first report to show dynamic alterations in plasma metabolite concentrations, as assessed using capillary electrophoresis time-of-flight mass spectrometry, in morbidly obese patients after LSG. Our results might show how LSG helps improve obesity, in part through metabolic status changes, and propose novel therapeutic targets to ameliorate obesity.

収録刊行物

• Journal of Diabetes Investigation

  Journal of Diabetes Investigation 12 (1), 123-129, 2021-01

  Wiley

キーワード

• Laparoscopic sleeve gastrectomy
• Metabolites
• Obesity

詳細情報

• CRID: 1050012570392210304
• NII論文ID: 120006952753
• NII書誌ID: AA12488319
• ISSN: 20401124
• ISSN: 20401116
• HANDLE: 20.500.14094/90007769
• Web Site: https://search.jamas.or.jp/link/ui/2021267224
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles