Epithelial cell-turnover ensures robust coordination of tissue growth in Drosophila ribosomal protein mutants

• Akai, Nanami

• Ohsawa, Shizue

• Sando, Yukari

• Igaki, Tatsushi

抄録

Highly reproducible tissue development is achieved by robust, time-dependent coordination of cell proliferation and cell death. To study the mechanisms underlying robust tissue growth, we analyzed the developmental process of wing imaginal discs in Drosophila Minute mutants, a series of heterozygous mutants for a ribosomal protein gene. Minute animals show significant developmental delay during the larval period but develop into essentially normal flies, suggesting there exists a mechanism ensuring robust tissue growth during abnormally prolonged developmental time. Surprisingly, we found that both cell death and compensatory cell proliferation were dramatically increased in developing wing pouches of Minute animals. Blocking the cell-turnover by inhibiting cell death resulted in morphological defects, indicating the essential role of cell-turnover in Minute wing morphogenesis. Our analyses showed that Minute wing discs elevate Wg expression and JNK-mediated Dilp8 expression that causes developmental delay, both of which are necessary for the induction of cell-turnover. Furthermore, forced increase in Wg expression together with developmental delay caused by ecdysone depletion induced cell-turnover in the wing pouches of non-Minute animals. Our findings suggest a novel paradigm for robust coordination of tissue growth by cell-turnover, which is induced when developmental time axis is distorted.

体の成長と組織の成長の速度を調節する仕組みをハエで解明 --進化のメカニズムに関わる可能性--. 京都大学プレスリリース. 2021-01-29.

収録刊行物

• PLOS Genetics

  PLOS Genetics 17 (1), 2021-01-28

  Public Library of Science (PLoS)

詳細情報

• CRID: 1050005508516247936
• NII論文ID: 120006954062
• ISSN: 15537404
• HANDLE: 2433/261186
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles