GPI-AP release in cellular, developmental, and reproductive biology

• Fujihara, Yoshitaka

• Ikawa, Masahito

抄録

Yoshitaka Fujihara, Masahito Ikawa, GPI-AP release in cellular, developmental, and reproductive biology, Journal of Lipid Research, Volume 57, Issue 4, 2016, Pages 538-545, ISSN 0022-2275, https://doi.org/10.1194/jlr.R063032.

Glycosylphosphatidylinositol-anchored proteins (GPI-APs) contain a covalently linked GPI anchor located on outer cell membranes. GPI-APs are ubiquitously conserved from protozoa to vertebrates and are critical for physiological events such as development, immunity, and neurogenesis in vertebrates. Both membrane-anchored and soluble GPI-APs play a role in regulating their protein conformation and functional properties. Several pathways mediate the release of GPI-APs from the plasma membrane by vesiculation or cleavage. Phospholipases and putative substrate-specific GPI-AP-releasing enzymes, such as NOTUM, glycerophosphodiesterase 2, and angiotensin-converting enzyme, have been characterized in mammals. Here, the protein modifications resulting from the cleavage of the GPI anchor are discussed in the context of its physiological functions.

収録刊行物

• Journal of Lipid Research

  Journal of Lipid Research 57 (4), 538-545, 2016-04

  American Society for Biochemistry and Molecular Biology Inc.

キーワード

• Gene expression
• Genetics
• Glycosylphosphatidylinositol-anchored protein
• Glypican
• GPIase
• IZUMO1 receptor/JUNO
• Membranes
• Phospholipases
• Phospholipids/phosphatidylinositol
• Reversion-inducing cysteine-rich protein with kazal motifs
• Testis-expressed gene 101

詳細情報

• CRID: 1050018218948099328
• NII論文ID: 120006957424
• NII書誌ID: AA12050067
• ISSN: 15397262
• ISSN: 00222275
• HANDLE: 11094/78590
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles