Bakuchiol Is a Phenolic Isoprenoid with Novel Enantiomer-selective Anti-influenza A Virus Activity Involving Nrf2 Activation

• Shoji, Masaki

• Arakaki, Yumie

• Esumi, Tomoyuki

• Kohnomi, Shuntaro

• Yamamoto, Chihiro

• Suzuki, Yutaka

• Takahashi, Etsuhisa

• Konishi, Shiro

• Kido, Hiroshi

• Kuzuhara, Takashi

Bibliographic Information

Other Title

• Enantiomer-selective Anti-influenza Activity of Bakuchiol

Abstract

Background: Novel therapeutic approaches against influenza are required. Bakuchiol is a phenolic isoprenoid found in Babchi seeds. Results: Bakuchiol enantiomer-selectively inhibited influenza A viral infection and growth and activated the Nrf2 pathway. Conclusion: Bakuchiol showed novel enantiomer-selective anti-influenza viral activity. Significance: The study of bakuchiol will contribute to the development of novel approaches to influenza therapy.

Journal

• Journal of Biological Chemistry

  Journal of Biological Chemistry 290 (46), 28001-28017, 2015-10-07

  The American Society for Biochemistry and Molecular Biology

Details

• CRID: 1050850092109826432
• NII Article ID: 120006959751
• NII Book ID: AA1202441X
• ISSN: 00219258
• Web Site: http://repo.lib.tokushima-u.ac.jp/115492
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles