The biosynthetic pathway of potato solanidanes diverged from that of spirosolanes due to evolution of a dioxygenase

• Akiyama, Ryota

• Watanabe, Bunta

• 中安, 大

• 李, ヒョン宰

• Kato, Junpei

• Umemoto, Naoyuki

• Muranaka, Toshiya

• Saito, Kazuki

• 杉本, 幸裕

• 水谷, 正治

抄録

Potato (Solanum tuberosum), a worldwide major food crop, produces the toxic, bitter tasting solanidane glycoalkaloids α-solanine and α-chaconine. Controlling levels of glycoalkaloids is an important focus on potato breeding. Tomato (Solanum lycopersicum) contains a bitter spirosolane glycoalkaloid, α-tomatine. These glycoalkaloids are biosynthesized from cholesterol via a partly common pathway, although the mechanisms giving rise to the structural differences between solanidane and spirosolane remained elusive. Here we identify a 2-oxoglutarate dependent dioxygenase, designated as DPS (Dioxygenase for Potato Solanidane synthesis), that is a key enzyme for solanidane glycoalkaloid biosynthesis in potato. DPS catalyzes the ring-rearrangement from spirosolane to solanidane via C-16 hydroxylation. Evolutionary divergence of spirosolane-metabolizing dioxygenases contributes to the emergence of toxic solanidane glycoalkaloids in potato and the chemical diversity in Solanaceae.

収録刊行物

• Nature Communications

  Nature Communications 12 (1), 1300-, 2021-02-26

  Nature Research

キーワード

• Oxidoreductases
• Secondary metabolism

詳細情報

• CRID: 1050575520345566592
• NII論文ID: 120007006642
• NII論文ID: 120006979781
• NII書誌ID: AA12645905
• DOI: 10.1038/s41467-021-21546-0
• ISSN: 20411723
• HANDLE: 20.500.14094/90008097
• HANDLE: 2433/261818
• Web Site: https://www.nature.com/articles/s41467-021-21546-0.pdf
• Web Site: https://www.nature.com/articles/s41467-021-21546-0
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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