ER-resident sensor PERK is essential for mitochondrial thermogenesis in brown adipose tissue

• Kato, Hironori

• Okabe, Kohki

• Miyake, Masato

• Hattori, Kazuki

• Fukaya, Tomohiro

• Tanimoto, Kousuke

• Beini, Shi

• Mizuguchi, Mariko

• Torii, Satoru

• Arakawa, Satoko

• Ono, Masaya

• Saito, Yusuke

• Sugiyama, Takashi

• Funatsu, Takashi

• Sato, Katsuaki

• Shimizu, Shigeomi

• Oyadomari, Seiichi

• Ichijo, Hidenori

• Kadowaki, Hisae

• Nishitoh, Hideki

書誌事項

タイトル別名

• Role of PERK in mitochondrial function

抄録

Mitochondria play a central role in the function of brown adipocytes (BAs). Although mitochondrial biogenesis, which is indispensable for thermogenesis, is regulated by coordination between nuclear DNA transcription and mitochondrial DNA transcription, the molecular mechanisms of mitochondrial development during BA differentiation are largely unknown. Here, we show the importance of the ER-resident sensor PKR-like ER kinase (PERK) in the mitochondrial thermogenesis of brown adipose tissue. During BA differentiation, PERK is physiologically phosphorylated independently of the ER stress. This PERK phosphorylation induces transcriptional activation by GA-binding protein transcription factor α subunit (GABPα), which is required for mitochondrial inner membrane protein biogenesis, and this novel role of PERK is involved in maintaining the body temperatures of mice during cold exposure. Our findings demonstrate that mitochondrial development regulated by the PERK–GABPα axis is indispensable for thermogenesis in brown adipose tissue.

収録刊行物

• Life Science Alliance

  Life Science Alliance 3 (3), e201900576-, 2020-02-06

  Life Science Alliance

キーワード

• Health, Toxicology and Mutagenesis
• Plant Science
• Biochemistry, Genetics and Molecular Biology (miscellaneous)
• Ecology

詳細情報

• CRID: 1050568772226760704
• NII論文ID: 120006980545
• ISSN: 25751077
• DOI: 10.26508/lsa.201900576
• Web Site: http://repo.lib.tokushima-u.ac.jp/115577
• Web Site: https://syndication.highwire.org/content/doi/10.26508/lsa.201900576
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN