Nonenzymatic kinetic resolution of 3-hydroxyalkanamides with chiral copper catalyst

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Abstract

Kinetic resolution of 3-hydroxyalkanamides with good to high selectivities was achieved by benzoylation using copper(II) triflate and (R,R)-PhBox [2,2′-isopropylidenebis(4-phenyl-2-oxazoline)] as catalyst, which also mediated enantioselective tosylation of 2,2-bis(hydroxymethyl)alkanamides with high efficiency.

Synlett, 3, pp.433-437; 2008

Journal

  • Synlett

    Synlett (3), 433-437, 2008-02-12

    Thieme

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