Prolonged gabapentin analgesia in an experimental mouse model of fibromyalgia.

• Nishiyori, Michiko

• Ueda, Hiroshi

Abstract

In a new mouse model for generalized pain syndrome, including fibromyalgia, which used intermittent cold stress (ICS), bilateral allodynia in the hindpaw was observed that lasted more than 12 days; thermal hyperalgesia lasted 15 days. During constant cold stress (CCS), mice showed only a transient allodynia. A female prevalence in ICS-induced allodynia was observed in gonadectomized but not in gonad intact mice. Systemic gabapentin showed complete anti-allodynic effects in the ICS model at the one-tenth dose for injury-induced neuropathic pain model, and central gabapentin showed long-lasting analgesia for 4 days in ICS, but not the injury model. These results suggest that the ICS model is useful for the study of generalized pain syndrome.

Molecular Pain, 4, 52; 2008

Journal

• Molecular pain

  Molecular pain 4 52-, 2008-11-06

  BioMed Central

Details

• CRID: 1050287297239443200
• NII Article ID: 120006983382
• ISSN: 17448069
• HANDLE: 10069/20861
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/17036
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles