Elevated levels of high mobility group box chromosomal protein-1 (HMGB-1) in sera from patients with severe bacterial pneumonia coinfected with influenza virus.

• Kosai, Kosuke

• Seki, Masafumi

• Yanagihara, Katsunori

• Nakamura, Shigeki

• Kurihara, Shintaro

• Izumikawa, Koichi

• Kakeya, Hiroshi

• Yamamoto, Yoshihiro

• Tashiro, Takayoshi

• Kohno, Shigeru

Abstract

Plasma levels of high mobility group box chromosomal protein-1 (HMGB-1), as well as of other inflammatory molecules such as interleukin-6 (IL-6), regulated on activation normal T-cell expressed and secreted (RANTES), and soluble intercellular adhesion molecule-1 (sICAM-1), were determined in patients with bacterial pneumonia coinfected with influenza virus. HMGB-1 levels were significantly elevated in these patients compared to patients undergoing mild bacterial pneumonia alone (p < 0.01). Among cases of coinfection, we found a significant correlation between the concentration of HMGB-1 and white blood cell counts (p < 0.05, r = 0.612). Levels of IL-6 were also higher in these patients than in patients with bacterial pneumonia alone (p < 0.05), despite similar levels of RANTES and sICAM-1 in the 2 groups. These data suggest that HMGB-1 is involved in the pathogenesis of severe bacterial pneumonia coinfected with influenza virus.

Scandinavian journal of infectious diseases, 40(4), pp.338-342; 2008

Journal

• Scandinavian journal of infectious diseases

  Scandinavian journal of infectious diseases 40 (4), 338-342, 2008

  Taylor & Francis

Keywords

• HMGB-1
• influenza virus
• bacterial pneumonia
• co-infection

Details

• CRID: 1050287297251279232
• NII Article ID: 120006983755
• NII Book ID: AA00833588
• ISSN: 00365548
• ISSN: 16511980
• HANDLE: 10069/22523
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/16641
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles