Roles of the Valine Clusters in Domain 3 of the Hemolytic Lectin CEL-III in Its Oligomerization and Hemolytic Abilities

• Hisamatsu, Keigo

• Unno, Hideaki

• Goda, Shuichiro

• Hatakeyama, Tomomitsu

抄録

The hemolytic lectin CEL-III and its site-directed mutants were expressed in Escherichia coli cells. Replacement of the valine clusters in domain 3 with alanine residues led to increased self-oligomerization in solution and higher hemolytic activity. The results suggest the involvement of these valine clusters in CEL-III oligomerization and hemolytic activity.

Protein and Peptide Letters, 16(4), pp.411-414; 2009

収録刊行物

• Protein and Peptide Letters

  Protein and Peptide Letters 16 (4), 411-414, 2009-04-01

  Bentham Science Publishers

キーワード

• Cucumaria echinata
• Hemolysin
• Lectin
• Oligomerization
• Site-directed mutagenesis

詳細情報

• CRID: 1050005822262855680
• NII論文ID: 120006984476
• NII書誌ID: AA1102463X
• ISSN: 09298665
• HANDLE: 10069/23319
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/15422
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles
  • KAKEN