Roles of calcineurin and Crz1 in antifungal susceptibility and virulence of Candida glabrata.

• Miyazaki, Taiga

• Yamauchi, Shunsuke

• Inamine, Tatsuo

• Nagayoshi, Yosuke

• Saijo, Tomomi

• Izumikawa, Koichi

• Seki, Masafumi

• Kakeya, Hiroshi

• Yamamoto, Yoshihiro

• Yanagihara, Katsunori

• Miyazaki, Yoshitsugu

• Kohno, Shigeru

Abstract

A Candida glabrata calcineurin mutant exhibited increased susceptibility to both azole antifungal and cell wall-damaging agents and was also attenuated in virulence. Although a mutant lacking the downstream transcription factor Crz1 displayed a cell wall-associated phenotype intermediate to that of the calcineurin mutant and was modestly attenuated in virulence, it did not show increased azole susceptibility. These results suggest that calcineurin regulates both Crz1-dependent and -independent pathways depending on the type of stress.

Antimicrobial agents and chemotherapy, 54(4), pp.1639-1643; 2010

Journal

• Antimicrobial agents and chemotherapy

  Antimicrobial agents and chemotherapy 54 (4), 1639-1643, 2010-04

  American Society for Microbiology

Details

• CRID: 1050287297239576192
• NII Article ID: 120006984565
• NII Book ID: AA00542574
• ISSN: 00664804
• ISSN: 10986596
• HANDLE: 10069/23140
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/15263
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles