In vivo efficacy of sivelestat in combination with pazufloxacin against Legionella pneumonia.

• Morinaga, Yoshitomo

• Yanagihara, Katsunori

• Araki, Nobuko

• Yamada, Koichi

• Seki, Masafumi

• Izumikawa, Koichi

• Kakeya, Hiroshi

• Yamamoto, Yoshihiro

• Yamada, Yasuaki

• Kohno, Shigeru

• Kamihira, Shimeru

Abstract

It is important to regulate excessive inflammation when patients with severe infectious disease are treated. Sivelestat sodium hydrate (sivelestat), a neutrophil elastase inhibitor, is used in the treatment of lung injury but its effect on bacterial pneumonia is unknown. The authors examined the efficacy of sivelestat in combination with a fluoroquinolone in a Legionella pneumophila pneumonia mouse model. The combination therapy did not show a significant survival improvement compared to the treatment with fluoroquinolone alone, but reduced bacteria number and inflammatory cells in the early phase. The combination therapy can contribute to treatment of L. pneumophila pneumonia with protecting lungs.

Experimental lung research, 36(8), pp.484-490; 2010

Journal

• Experimental lung research

  Experimental lung research 36 (8), 484-490, 2010-10

  Informa Healthcare USA, Inc.

Keywords

• Legionella pneumophila
• neutrophil elastase severe pneumonia

Details

• CRID: 1050850247216420352
• NII Article ID: 120006984903
• NII Book ID: AA00181680
• ISSN: 01902148
• ISSN: 15210499
• HANDLE: 10069/25920
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/14536
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles