Functional characterization of the regulators of calcineurin in Candida glabrata

• Miyazaki, Taiga

• Izumikawa, Koichi

• Nagayoshi, Yohsuke

• Saijo, Tomomi

• Yamauchi, Shunsuke

• Morinaga, Yoshitomo

• Seki, Masafumi

• Kakeya, Hiroshi

• Yamamoto, Yoshihiro

• Yanagihara, Katsunori

• Miyazaki, Yoshitsugu

• Kohno, Shigeru

Abstract

The serine-threonine-specific protein phosphatase calcineurin is a key mediator of various stress responses in fungi. Herein, we characterized functions of the endogenous regulators of calcineurin (RCNs), Rcn1 and Rcn2, in the pathogenic fungus Candida glabrata. Rcn1 exerted both inhibitory and stimulatory effects on calcineurin signaling, but Rcn2 displayed only inhibitory activity. Phenotypic analyses of C. glabrata strains lacking either RCNs, calcineurin, or both revealed that calcineurin requires Rcn1, but not Rcn2, for antifungal tolerance in C. glabrata.

FEMS Yeast Research, 11(8), pp.621-630; 2011

Journal

• FEMS Yeast Research

  FEMS Yeast Research 11 (8), 621-630, 2011-12

  Blackwell Publishing Inc.

Keywords

• Antifungal resistance
• Crz1
• Rcn1
• Rcn2

Details

• CRID: 1050568772251645056
• NII Article ID: 120006985354
• NII Book ID: AA11577311
• ISSN: 15671356
• ISSN: 15671364
• HANDLE: 10069/27451
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/11099
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles