Direct protective effects of dexmedetomidine against myocardial ischemia-reperfusion injury in anesthetized pigs

• Yoshitomi, Osamu

• Cho, Sungsam

• Hara, Tetsuya

• Shibata, Itsuko

• Maekawa, Takuji

• Ureshino, Hiroyuki

• Sumikawa, Koji

抄録

Systemic administration of α2-adrenergic agonists has been shown to protect ischemic myocardium, but the direct effects on ischemia-reperfused myocardium have not yet been clarified. This study was carried out to determine the effects of intracoronary dexmedetomidine (DEX) on the myocardial ischemia-reperfusion injury in anesthetized pigs. In open-chest pigs, the left anterior descending coronary artery was perfused through an extracorporeal circuit from the carotid artery. They received intracoronary infusion of DEX at a rate of 1 ng • mL -1 (group LD, n = 9), 10 ng • mL -1 (group MD, n = 9), or 100 ng • mL -1 (group HD, n = 9) of coronary blood flow or vehicle (group C, n = 12) for 30 min before ischemia. Myocardial stunning was produced by 12-min ischemia of the perfused area of left anterior descending coronary artery and 90-min reperfusion. The effect on reperfusion-induced arrhythmias was evaluated using the incidence of ventricular tachycardia or fibrillation after reperfusion. Regional myocardial contractility was evaluated with segment shortening (%SS). Dexmedetomidine significantly reduced the incidence of reperfusion-induced ventricular arrhythmias. Dexmedetomidine significantly improved the recovery of percentage segment shortening at 90 min after reperfusion (32.6% ± 3.1% in group C, 58.2% ± 2.1% in group LD, 61.1% ± 1.8% in group MD, and 72.0% ± 2.0% in group HD). Dexmedetomidine suppressed the increase in plasma norepinephrine concentration after reperfusion. The results indicate that DEX would exert the protective effect against ischemia-reperfusion injury by the direct action on the myocardium, which is not mediated through the central nervous system.

Shock, 38(1), pp.92-97; 2012

収録刊行物

• Shock

  Shock 38 (1), 92-97, 2012-07

  Lippincott Williams and Wilkins

キーワード

• dexmedetomidine
• myocardial stunning
• norepinephrine
• α2-adrenergic agonist
• myocardial ischemia

詳細情報

• CRID: 1050850247216700416
• NII論文ID: 120006985371
• ISSN: 10732322
• DOI: 10.1097/shk.0b013e318254d3fb
• HANDLE: 10069/29498
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/10933
• Web Site: https://journals.lww.com/10.1097/SHK.0b013e318254d3fb
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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  • Crossref
  • CiNii Articles
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