Muscle Stem Cell Fate Is Controlled by the Cell-Polarity Protein Scrib

機関リポジトリ HANDLE

抄録

Satellite cells are resident skeletal muscle stem cells that supply myonuclei for homeostasis, hypertrophy, and repair in adult muscle. Scrib is one of the major cell-polarity proteins, acting as a potent tumor suppressor in epithelial cells. Here, we show that Scrib also controls satellite-cell-fate decisions in adult mice. Scrib is undetectable in quiescent cells but becomes expressed during activation. Scrib isasymmetrically distributed in dividing daughter cells, with robust accumulation in cells committed to myogenic differentiation. Low Scrib expression is associated with the proliferative state and preventing self-renewal, whereas high Scrib levels reduce satellite cell proliferation. Satellite-cell-specific knockout of Scrib in mice causes a drastic andinsurmountable defect in muscle regeneration. Thus, Scrib is a regulator of tissue stem cells, controlling population expansion and self-renewal with Scrib expression dynamics directing satellite cell fate.

Cell Reports, 10(7), pp.1135-1148; 2015

収録刊行物

  • Cell Reports

    Cell Reports 10 (7), 1135-1148, 2015-02-24

    Cell Press

詳細情報 詳細情報について

問題の指摘

ページトップへ