Synthesis of Lamellarins via Regioselective Assembly of 1,2-Diarylated [1]Benzopyrano[3,4-b]pyrrol-4(3H)-one Core

• Fukuda, Tsutomu

• Katae, Takatoshi

• Harada, Issei

• Iwao, Masatomo

Abstract

A modular synthesis of lamellarins has been developed. The key reactions in this synthesis are the assembly of 1,2-diarylated [1]benzopyrano[3,4-b]pyrrol-4(3H)-ones from a preexisting [1]benzopyrano[3,4-b]pyrrol-4(3H)-one core and the appropriate arylboronic acids. The obtained 1,2-diarylated [1]benzopyrano[3,4-b]pyrrol-4(3H)-ones could be easily converted into the corresponding lamellarin derivatives by intramolecular annulation between the pyrrole nitrogen and the C2 aromatic ring.

HETEROCYCLES, 95(2), pp.950-971; 2017

Journal

• HETEROCYCLES

  HETEROCYCLES 95 (2), 950-971, 2017

  日本複素環化学研究所

Keywords

• Organic Chemistry
• Pharmacology
• Analytical Chemistry

Details

• CRID: 1050850247228953856
• NII Article ID: 120006987527
• NII Book ID: AA00663739
• ISSN: 03855414
• DOI: 10.3987/com-16-s(s)63
• HANDLE: 10069/37532
• NDL BIB ID: 028213983
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/2325
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I028213983
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • NDL
  • Crossref
  • CiNii Articles
  • KAKEN