Association of serum levels of fibrosis-related biomarkers with disease activity in patients with IgG4-related disease

• Kawashiri, Shin-ya

• Origuchi, Tomoki

• Umeda, Masataka

• Nishino, Ayako

• Shimizu, Toshimasa

• Fukui, Shoichi

• Koga, Tomohiro

• Iwamoto, Naoki

• Ichinose, Kunihiro

• Tamai, Mami

• Nakamura, Hideki

• Maeda, Takahiro

• Kawano, Mitsuhiro

• Yamamoto, Motohisa

• Izumi, Yasumori

• Kawakami, Atsushi

Abstract

Background: The aim of this study was to identify fibrosis-related serological surrogate outcome measures in patients with immunoglobulin G4-related disease (IgG4-RD). Methods: This was a clinical observational study of 72 patients with untreated IgG4-RD from four institutions in Japan.The serum concentrations of growth differentiation factor 15 (GDF-15), CCL2, hyaluronic acid (HA), amino-terminal propeptide of type III procollagen (PIIINP), and tissue inhibitor of metalloproteinases 1 (TIMP-1) were measured by enzyme-linked immunosorbent assays. The enhanced liver fibrosis (ELF) score was calculated from the TIMP-1, PIIINP, and HA values. We evaluated associations between the values of these biomarkers and laboratory data, the IgG4-RD responder index (IgG4-RD RI) score, and organ involvements. Results: Compared with the 44 healthy controls, the patients with IgG4-RD showed significantly elevated serum concentrations of GDF-15, MCP-1, HA, PIIINP, and TIMP-1 and ELF scores. The patients' serum concentrations of GDF-15, CCL2, HA, and TIMP-1 (but not PIIINP) were positively correlated with each other. Among them, serum GDF-15 most efficiently distinguished patients with IgG4-RD from healthy controls. Serum GDF-15 was not associated with the IgG4-RD RI score or the number of organ involvements but was independently associated with the presence of retroperitoneal fibrosis and with parotid gland involvement. Conclusions: We observed increased serological surrogate outcome measures of fibrosis in IgG4-RD. GDF-15 may precisely reflect the fibrotic degree in patients with IgG4-RD.

Arthritis Research and Therapy, 20(1), art.no.277; 2018

Journal

• Arthritis Research & Therapy

  Arthritis Research & Therapy 20 (1), 277-, 2018-12-14

  BioMed Central Ltd.

Keywords

• IgG4-related disease
• Fibrosis
• GDF-15 organ involvement
• Prednisolone
• Responder index

Details

• CRID: 1050850247229020544
• NII Article ID: 120006987867
• ISSN: 14786362
• DOI: 10.1186/s13075-018-1777-7
• HANDLE: 10069/38770
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/1505
• Web Site: http://link.springer.com/content/pdf/10.1186/s13075-018-1777-7.pdf
• Web Site: http://link.springer.com/article/10.1186/s13075-018-1777-7/fulltext.html
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN