Reversible Cognitive Dysfunction in Elderly-onset Systemic Lupus Erythematosus, Successfully Treated with Aggressive Immunosuppressive Therapy

• Fujita Yuya

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Fukui Shoichi

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Ishida Midori

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Endo Yushiro

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Tsuji Sosuke

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Takatani Ayuko

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Igawa Takashi

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Shimizu Toshimasa

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Umeda Masataka

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan Medical Education Development Center, Nagasaki University Hospital, Japan

• Sumiyoshi Remi

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Nishino Ayako

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan Center for Comprehensive Community Care Education Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Koga Tomohiro

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan Center for Bioinformatics and Molecular Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Kawashiri Shin-ya

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan Department of Community Medicine, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Iwamoto Naoki

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Ichinose Kunihiro

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Tamai Mami

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Nakamura Hideki

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Origuchi Tomoki

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan Department of Rehabilitation Sciences, Nagasaki University Graduate School of Biomedical Sciences, Japan

• Kawakami Atsushi

  Department of Immunology and Rheumatology, Nagasaki University Graduate School of Biomedical Sciences, Japan

Abstract

A 70-year-old Japanese woman presented to our hospital with gait disturbance and cognitive dysfunction. Since she had arthritis, lymphopenia, hypocomplementemia, and anti-nuclear and anti-double-stranded DNA antibodies, she was diagnosed with systemic lupus erythematosus (SLE). T2-weighted magnetic resonance imaging revealed bilateral hyperintensities in the putamen. Based on her cognitive impairment, muscle rigidity, and high levels of interleukin-6 in the cerebrospinal fluid, we believed she had developed a complication of a neuropsychiatric disease and administered corticosteroids and intravenous cyclophosphamide therapy. Her cognitive function fully recovered, and her gait disturbance improved. Attending to cognitive impairment in elderly SLE patients is necessary.

Journal

• Internal Medicine

  Internal Medicine 57 (20), 3025-3028, 2018-10-15

  The Japanese Society of Internal Medicine

Keywords

• cognitive dysfunction
• systemic lupus erythematosus
• immunosuppressive therapy

Details

• CRID: 1390564238035325568
• NII Article ID: 120006987912
• DOI: 10.2169/internalmedicine.0934-18
• ISSN: 13497235
• ISSN: 09182918
• HANDLE: 10069/38686
• PubMed: 29780145
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/1422
• Web Site: https://www.jstage.jst.go.jp/article/internalmedicine/57/20/57_0934-18/_pdf
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • Crossref
  • PubMed
  • CiNii Articles
  • KAKEN
• Abstract License Flag: Disallowed