In Vitro Activity of Lascufloxacin against Streptococcus pneumoniae with Mutations in the Quinolone Resistance-Determining Regions
Abstract
Lascufloxacin showed potent activity against Streptococcus pneumoniae with a GyrA or ParC mutation (first-step mutant). The frequency of selecting resistant strains tended to be lower for lascufloxacin than for levofloxacin and garenoxacin after drug exposure in first-step mutants but was similar in the comparison between lascufloxacin and moxifloxacin. The increase in MIC was smaller for lascufloxacin than for levofloxacin, garenoxacin, and moxifloxacin when clinical strains with only ParC mutations were exposed to the corresponding drug.
Antimicrobial Agents and Chemotherapy, 62(4), 01971-17; 2018
Journal
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- Antimicrobial Agents and Chemotherapy
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Antimicrobial Agents and Chemotherapy 62 (4), 01971-17-, 2018-04
American Society for Microbiology
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Details 詳細情報について
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- CRID
- 1050850247217382272
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- NII Article ID
- 120006988021
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- ISSN
- 00664804
- 10986596
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- HANDLE
- 10069/38449
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- CiNii Articles