Thymus and Activation-regulated Chemokine as a Biomarker for IgG4-related Disease

• Umeda, Masataka

• Origuchi, Tomoki

• Kawashiri, Shin-ya

• Koga, Tomohiro

• Ichinose, Kunihiro

• Furukawa, Kaori

• Sato, Tomohito

• Tsuji, Sousuke

• Endo, Yushiro

• Takatani, Ayuko

• Shimizu, Toshimasa

• Fukui, Shoichi

• Iwamoto, Naoki

• Igawa, Takashi

• Tamai, Mami

• Nakamura, Hideki

• Kawakami, Atsushi

Abstract

High serum concentrations of thymus and activation-regulated chemokine (TARC) are observed in allergic diseases such as atopic dermatitis and bronchial asthma. Frequent allergic symptoms have been reported in patients with IgG4-related disease (IgG4-RD). We investigated the pathogenic role of TARC as a biomarker in IgG4-RD patients. We evaluated the serum concentrations of TARC from 29 IgG4-RD patients, 28 primary Sjogren syndrome (pSS) patients, and 23 healthy controls (HCs) by enzyme-linked immunosorbent assay (ELISA). We analyzed the correlations between the TARC concentrations and the subjects’ clinical parameters. To investigate the biological effect of TARC on the pathogenesis of IgG4-RD, we evaluated the in vitro induction of plasmablasts from IgG4-RD patients by TARC. The serum concentrations of TARC in the IgG4-RD patients were significantly higher than those of the pSS patients and HCs. The serum TARC concentration of the IgG4-RD group was positively correlated with the IgG4-RD responder index (IgG4-RD RI) score and with the number of organs involved, but it was not correlated with the serum IgG4 level or eosinophil number in the IgG4-RD patients’ peripheral blood. The patients who had lung involvement had higher serum TARC concentrations. In vitro, TARC clearly induced the formation of plasmablasts from the IgG4-RD patients’ peripheral blood mononuclear cells. Collectively, our data suggest that a systemic increment of TARC may contribute to the development of IgG4-RD through an aberrant induction of plasmablasts.

Scientific reports, 10(1), art.no.6010; 2020

Journal

• Scientific Reports

  Scientific Reports 10 (1), 6010-, 2020-04-07

  Springer Nature

Keywords

• Multidisciplinary

Details

• CRID: 1050850247205834240
• NII Article ID: 120006988235
• ISSN: 20452322
• DOI: 10.1038/s41598-020-62941-9
• HANDLE: 10069/39887
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/708
• Web Site: https://www.nature.com/articles/s41598-020-62941-9.pdf
• Web Site: https://www.nature.com/articles/s41598-020-62941-9
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN