Pathogenetic Potential Relating to Metabolic Activity in a Mouse Model of Infection with the Chikungunya Virus East/Central/South African Genotype

• Ngwe, Tun Mya Myat

• Muthugala, Rohitha

• Kyaw, Kyaw Aung

• Shimada, Satoshi

• Morita, Kouichi

• Hayasaka, Daisuke

Abstract

Epidemics of the Chikungunya virus (CHIKV) from 2004 onwards were caused by the East/Central/South African (ECSA) genotype. However, the pathogenesis of the genotype infection has not been fully explained. In this study, we examined the pathogenic potential of CHIKV ECSA genotype M-30 (M-30) by comparing it with that of African genotype S-27 (S-27) in mice. Following low titer infections in type-I IFN receptor KO (A129) mice, we found that the M-30 infection caused high and acute fatality compared with the S-27 infection. M-30-infected A129 mice showed higher viral loads in their central nervous systems and peripheral organs, and increased levels of IFN- responses in their brains. Interestingly, M-30-infected mice did not show the hypophagia and reductions in weight which were observed in S-27-infected mice. Our observations provide a novel explanation of the pathogenic mechanisms attributed to virus proliferation, anti-type-II IFN response and metabolic activity in the CHIKV ECSA virus in mice.

Viruses, 12(2), art.no.169; 2020

Journal

• Viruses

  Viruses 12 (2), 169-, 2020-02-03

  MDPI

Keywords

• CHIKV
• ECSA
• mouse model
• viral pathogenesis

Details

• CRID: 1050568772252373504
• NII Article ID: 120006988301
• ISSN: 19994915
• DOI: 10.3390/v12020169
• HANDLE: 10069/39666
• Web Site: https://nagasaki-u.repo.nii.ac.jp/records/499
• Web Site: https://www.mdpi.com/1999-4915/12/2/169/pdf
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN