Intake frequency of vegetables or seafoods negatively correlates with disease activity of rheumatoid arthritis

• Murakami, Isao

• Murakami, Kosaku

• Hashimoto, Motomu

• Tanaka, Masao

• Ito, Hiromu

• Fujii, Takao

• Torii, Mie

• Ikeda, Kaori

• Kuwabara, Akiko

• Tanaka, Kiyoshi

• Yoshida, Akiko

• Akizuki, Shuji

• Nakashima, Ran

• Yoshifuji, Hajime

• Ohmura, Koichiro

• Usui, Takashi

• Morita, Satoshi

• Mimori, Tsuneyo

• Jose M. Moran

  editor

Abstract

Objective: To clarify the relationship between dietary habit and disease activity of rheumatoid arthritis (RA). Methods: This study enrolled RA patients who met the ACR/EULAR 2010 classification criteria from Kyoto University Rheumatoid Arthritis Management Alliance (KURAMA) cohort in 2015. 22-item food frequency questionnaire (FFQ) was taken for the measurement of dietary habit in a single-institution cohort of RA (Kyoto University Rheumatoid Arthritis Management Alliance: KURAMA) in 2015. The disease activities of RA using the Disease Activity Score calculated based on the erythrocyte sedimentation rate (DAS28-ESR), Simplified Disease Activity Index (SDAI), Health Assessment Questionnaire (HAQ), and serum matrix metalloproteinase-3 (MMP-3) level, the use of disease-modifying anti-rheumatic drugs (DMARDs), disease duration, rheumatoid factor, anti-cyclic citrullinated antibody, and body mass index were also examined. All of them were combined and statistically analyzed. Results: 441 RA patients (81% women; mean age 65 years; mean disease duration 15 years) were enrolled from the KURAMA cohort. Average Disease Activity Score-28 using the erythrocyte sedimentation rate (DAS28-ESR) was 2.7. Univariate analysis showed that intake frequency of vegetables had a statistically significant negative correlation with disease activity markers, such as DAS28-ESR (ρ = −0.11, p<0.01), Simplified Disease Activity Index (SDAI) (ρ = −0.16, p<0.001), matrix metalloproteinase-3 (MMP-3) (ρ = −0.21, p<0.0001), and Health Assessment Questionnaire (HAQ) (ρ = −0.13, p<0.01). Factor analysis with varimax rotation was done to simplify the relevance of disease activity to various food items. 22 foods were categorized into five dietary patterns: “seafoods”, “vegetables/fruits”, “meats/fried foods”, “snacks”, and “processed foods”. The multivariate analysis adjusted for clinically significant confounders showed that “seafoods” had statistically significant negative correlations with DAS28-ESR (β = −0.15, p<0.01), SDAI (β = −0.18, p<0.001), MMP-3 (β = −0.15, p<0.01), and HAQ (β = −0.24, p<0.0001). “Vegetables/fruits” had statistically significant negative correlations with SDAI (β = −0.11 p<0.05), MMP-3 (β = −0.12, p<0.01), and HAQ (β = −0.11, p<0.05) Conclusions: These results suggest that high intake frequency of vegetables/fruits and/or seafoods might correlate with low disease activity.

Journal

• PLoS ONE

  PLoS ONE 15 (2), e0228852-, 2020-02-13

  Public Library of Science (PLoS)

Keywords

• Multidisciplinary

Details

• CRID: 1050568937758884736
• NII Article ID: 120006993973
• ISSN: 19326203
• DOI: 10.1371/journal.pone.0228852
• HANDLE: 2433/261998
• Web Site: https://dx.plos.org/10.1371/journal.pone.0228852
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN