アトピー性皮膚炎の発症機序2020

• 古江 増隆

  九州大学病院油症ダイオキシン研究診療センター 九州大学大学院医学研究院皮膚科学分野

書誌事項

タイトル別名

• Pathogenesis of Atopic Dermatitis 2020
• アトピーセイ ヒフエン ノ ハッショウ キジョ 2020

抄録

Atopic dermatitis (AD) is characterized by skin inflammation, barrier dysfunction and chronic pruritus. Excellent clinical efficacy of the anti-interleukin-4 (IL-4) receptor α antibody dupilumab underpins the pivotal roles of T helper type 2 (Th2) cytokines IL-13 and IL-4 in the pathogenesis of AD. Th2 cells also produce IL-31 which is the most important pruritogenic cytokine in AD. IL-13 and IL-4 downregulate the expression of filaggrin in keratinocytes and exacerbate epidermal barrier dysfunction. Keratinocytes in barrier-disrupted epidermis produce large amounts of thymic stromal lymphopoietin, IL-25 and IL-33, which contribute to Th2 immune deviation via OX40L/OX40 signaling. IL-13 and IL-4 also amplify the IL-31-mediated pruritus. In this review, I summarize recent advances in the pathogenesis of AD.

収録刊行物

• 福岡醫學雜誌

  福岡醫學雜誌 111 (4), 151-165, 2020-12-25

  福岡医学会

キーワード

• atopic dermatitis
• IL-4
• IL-13
• IL-31
• OX40
• IL-33
• thymic stromal lymphopoietin

詳細情報

• CRID: 1390572174733398272
• NII論文ID: 120006998845
• NII書誌ID: AN00215478
• DOI: 10.15017/4371064
• HANDLE: 2324/4371064
• NDL書誌ID: 031363758
• ISSN: 0016254X
• Web Site: https://ndlsearch.ndl.go.jp/books/R000000004-I031363758
• Web Site: https://search.jamas.or.jp/link/ui/2021193148
• 本文言語コード: ja
• データソース種別:
  • JaLC
  • IRDB
  • NDL
  • CiNii Articles
• 抄録ライセンスフラグ: 使用可