〈研究論文〉L-Lysineを側鎖にもつ生体適合性polyacrylamide存在下でのHepG2細胞応答性

• 小川, 智弘

• 農宗, 辰己

• 市原, 祐介

• 沖, 勇斗

• 白石, 浩平

書誌事項

タイトル別名

• 〈Original Papers〉HepG2 cell responsiveness in the presence of biocompatible polyacrylamide having L-Lysine as a side chain

抄録

[Abstract]We have been reported that amphoteric poly[Nα-acrylamide-L-lysine][poly(α-LysAA)] having L-Lysine as a side chain showed anti-thrombogenicity and enhanced fibrinolytic activity based on a selective binding activity with fibrinolytic proteins[plasminogen (Plg), tissue-type plasminogen activator (t-PA)]. To know biocompatibility for biomedical uses, the human hepatocellular carcinoma (HepG2 cell) responsiveness was evaluated in the presence of poly(α-LysAA). As the results from no effect on cell proliferation, cytotoxicity, and cell viability of HepG2 cells in the poly(α-LysAA)-contained medium or -coated dish, a bio-inert property of poly(α-LysAA) was shown.

Departmental Bulletin Paper

application/pdf

収録刊行物

• 近畿大学工学部研究報告

  近畿大学工学部研究報告 (54), 7-11, 2021-02-20

  近畿大学工学部

キーワード

• Amphoteric Polymer / Poly(acrylamide) / L-lysine / Evaluation of cell proliferation
• cytotoxicity
• and cell viability / HepG2 cells

詳細情報

• CRID: 1050850424365800448
• NII論文ID: 120007000214
• ISSN: 2434592X
• Web Site: https://kindai.repo.nii.ac.jp/records/21381
• 本文言語コード: ja
• 資料種別: departmental bulletin paper
• データソース種別:
  • IRDB
  • CiNii Articles