Complete Genome Sequences of Human Immunodeficiency Type 1 Viruses Genetically Engineered To Be Tropic for Rhesus Macaques

• Nomaguchi, Masako

• Doi, Naoya

• Koma, Takaaki

• Adachi, Akio

Abstract

We have constructed two human immunodeficiency type 1 (HIV-1) derivatives, CXCR4 tropic and CCR5 tropic, that replicate in rhesus macaques. They are genetically engineered to be resistant to macaque restriction factors against HIV-1, including TRIM5α, APOBEC3, and tetherin proteins. The two HIV-1 variants described here are fundamental clones aiming for rhesus infection studies of HIV-1.

Journal

• Genome Announcements

  Genome Announcements 5 (39), e01063-17-, 2017-09-28

  American Society for Microbiology

Keywords

• Genetics
• Molecular Biology

Details

• CRID: 1050569094143731584
• NII Article ID: 120007001411
• DOI: 10.1128/genomea.01063-17
• ISSN: 21698287
• Web Site: http://repo.lib.tokushima-u.ac.jp/115106
• Web Site: https://journals.asm.org/doi/pdf/10.1128/genomeA.01063-17
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN