Measurement of Tenascin-X in Synovial Fluid of Osteoarthritis Patients

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  • YAMADA Kazuo
    Department of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, Shimane 693-8501, Japan Department of Legal Medicine, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan
  • GONG Ao
    Department of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, Shimane 693-8501, Japan Department of Legal Medicine, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan Ningxia Medical University, Yinchuan, Ningxia, China
  • HASEGAWA Masahiro
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • HATTORI Tetsuya
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • SUDO Akihiro
    Department of Orthopaedic Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan
  • TAKESHITA Haruo
    Department of Legal Medicine, Faculty of Medicine, Shimane University, Izumo, Shimane 693-8501, Japan
  • MATSUMOTO Ken-ichi
    Department of Biosignaling and Radioisotope Experiment, Interdisciplinary Center for Science Research, Organization for Research and Academic Information, Shimane University, Izumo, Shimane 693-8501, Japan

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抄録

Osteoarthritis (OA) is a degenerative disorder that is characterized by articular cartilage destruction. The level of tenascin-C (TNC), an extracellular matrix protein, is increased in synovial fluid (SF) from OA patients, and TNC concentration in SF correlates with the severity of OA in the knee. Tenascin-X (TNX), another member of the tenascin family, has been identified as a causative protein of classical-like Ehlers-Danlos syndrome (clEDS). In this study, we investigated the correlation between TNX concentration and the degree of cartilage denaturation in OA patients. TNX concentrations in SF from patients with meniscus tears and from OA patients were lower than those of control sera. However, significant difference in TNX concentration in SF was not observed between patients with meniscus tears and OA patients. Furthermore, a significant correlation was not found between TNX concentration in SF and severity of OA in the knees of patients. These results suggest that TNX might not be as useful as TNC as a biomarker.

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