An innate interaction between IL-18 and the propeptide that inactivates its precursor form

• 堤, 尚孝

• 木村, 豪

• 加藤, 善一郎

• 深尾, 敏幸

• 白川, 昌宏

• 大西, 秀典

• 杤尾, 豪人

• Tochio, Hidehito

抄録

Uncontrolled secretion of mature interleukin (IL)-1β and IL-18 is responsible for severe autoinflammatory or autoimmune disorders and various allergic diseases. Here we report an intramolecular interaction between IL-18 and its propeptide, which is proteolytically removed from its precursor proIL-18 during maturation. The intramolecular interaction was recapitulated intermolecularly using recombinant propeptide. These results suggest the possibility of developing a novel class of peptide-based IL-18 inhibitors that could serve as therapeutic agents for IL-18-related inflammatory diseases.

収録刊行物

• Scientific Reports

  Scientific Reports 9 6160-, 2019-04-16

  Springer Nature

キーワード

• Interleukins
• NMR spectroscopy

詳細情報

• CRID: 1050006210048259840
• NII論文ID: 120007006235
• ISSN: 20452322
• DOI: 10.1038/s41598-019-42661-5
• HANDLE: 2433/250006
• Web Site: https://www.nature.com/articles/s41598-019-42661-5.pdf
• Web Site: https://www.nature.com/articles/s41598-019-42661-5
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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