Successful Treatment of Acute Promyelocytic Leukemia Complicated with Endometrial Cancer by Arsenic Trioxide

• Sugiura Hiroyuki

• Nishimori Hisakazu

• Matsuoka Hirofumi

• Nakamura Keiichiro

• Fujii Keiko

• Fujii Nobuharu

• Matsuoka Ken-ichi

• Maeda Yoshinobu

Abstract

Acute promyelocytic leukemia (APL) is a hematological emergency that requires urgent intervention because of the high incidence of early hemorrhagic death. When patients with APL experience a synchronous solid organ tumor, the tumor’s treatment must also be done properly. Differentiation-inducing therapy using arsenic trioxide (ATO) has less hematological toxicity compared to cytotoxic chemotherapy and might be preferable for untreated APL patients with a synchronous solid organ tumor. Here we describe the first successful case of untreated APL and synchronous endometrial cancer (in an adult Japanese woman) treated with ATO consolidation therapy and the subsequent surgery and chemotherapy for endometrial cancer.

Journal

• Acta Medica Okayama

  Acta Medica Okayama 75 (2), 219-224, 2021-04

  Okayama University Medical School

Keywords

• acute promyelocytic leukemia
• endometrial cancer
• arsenic trioxide
• synchronous multiple primary malignant tumor
• chemotherapy

Details

• CRID: 1390009224895176192
• NII Article ID: 120007029883
• NII Book ID: AA00508441
• ISSN: 0386300X
• DOI: 10.18926/amo/61904
• Web Site: https://ousar.lib.okayama-u.ac.jp/61904
• Web Site: https://search.jamas.or.jp/link/ui/2022085532
• Text Lang: en
• Data Source:
  • JaLC
  • IRDB
  • CiNii Articles