Detection of adenovirus hepatitis and acute liver failure in allogeneic hematopoietic stem cell transplant patients

• 恩田, 佳幸

• 諫田, 淳也

• 坂本, 宗一郎

• 岡田, 睦実

• 安齋, 尚之

• 馬止, 裕

• 田嶌, 政郎

• 羽賀, 博典

• Watanabe, Chihiro

• Hanaoka, Nozomu

• Fujimoto, Tsuguto

• 髙折, 晃史

抄録

Human adenovirus (HAdV) is an important cause of the common cold and epidemic keratoconjunctivitis in immunocompetent individuals. In immunocompromised patients, HAdV can sometimes cause severe infection such as cystitis, gastroenteritis, pneumonia, encephalitis, hepatitis, or disseminated disease, resulting in significant morbidity and also mortality. In particular, severe cases have been reported in patients after allogeneic hematopoietic stem cell transplantation (allo‐HSCT). Indeed HAdV has been recognized as a pathogen that requires careful monitoring in allo‐HSCT patients. While HAdV hepatitis leading to severe acute liver failure is rare, such liver failure progresses rapidly and is often fatal. Unfortunately, HAdV hepatitis has few characteristic symptoms and physical findings, which makes it difficult to promptly confirm and start treatment. We report here four cases of HAdV hepatitis after allo‐HSCT and their autopsy findings.

収録刊行物

• Transplant Infectious Disease

  Transplant Infectious Disease 23 (2), 2021-04

  willey

キーワード

• acute liver failure
• adenovirus hepatitis
• allo-HSCT

詳細情報

• CRID: 1050569767902722432
• NII論文ID: 120007041702
• ISSN: 13993062
• ISSN: 13982273
• HANDLE: 2433/263142
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles