Selective Mechanochemical Monoarylation of Unbiased Dibromoarenes by <i>in Situ</i> Crystallization

• Seo, Tamae

• Kubota, Koji

• Ito, Hajime

書誌事項

タイトル別名

• Selective Mechanochemical Monoarylation of Unbiased Dibromoarenes by in Situ Crystallization

抄録

Palladium-catalyzed Suzuki-Miyaura cross-coupling reactions of liquid, unbiased dibromoarenes under mechanochemical conditions selectively afford the monoarylated products. The lower reactivity of the crystalline monoarylated products relative to the liquid starting materials should be attributed predominantly to the low diffusion efficiency of the former in the reaction mixture, which results in a selective monoarylation. The present study sheds light on a novel approach using in situ phase transitions in solids to design selective organic transformations that are difficult to achieve via conventional solution-based synthesis.

収録刊行物

• Journal of the American Chemical Society

  Journal of the American Chemical Society 142 (22), 9884-9889, 2020-06-03

  American Chemical Society

キーワード

• Colloid and Surface Chemistry
• Biochemistry
• General Chemistry
• Catalysis

詳細情報

• CRID: 1050288292956330240
• NII論文ID: 120007042003
• DOI: 10.1021/jacs.0c01739
• ISSN: 15205126
• ISSN: 00027863
• HANDLE: 2115/81630
• Web Site: https://pubs.acs.org/doi/pdf/10.1021/jacs.0c01739
• 本文言語コード: en
• 資料種別: journal article
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