Disinfectant potential in inactivation of epidemic keratoconjunctivitis-related adenoviruses by potassium peroxymonosulfate

• Hashizume, Mei

• Aoki, Koki

• Ohno, Shigeaki

• Kitaichi, Nobuyoshi

• Yawata, Nobuyo

• Gonzalez, Gabriel

• Nonaka, Hirotaka

• Sato, Seiichi

• Takaoka, Akinori

Abstract

Purpose: The aim of this study was to test the antiviral effectivity of potassium peroxymonosulfate (RUBYSTA (R), KYORIN) against five epidemic keratoconjunctivitis-related types of Human adenovirus D in vitro. Methods: Five types of Human adenovirus D (8, 37, 53, 54 and 56) were incubated with 1% potassium peroxymonosulfate, 0.1% sodium hypochlorite (NaClO) or alcohol-based disinfectant for 30 s or 1 min. These solutions were subjected to measurements of viral titres by infection assays in A549 cells. At day 6 post-infection, both, supernatants and cells, were collected and the viral genome was assessed by real-time polymerase chain reaction analysis. Results: Treatments with 1% potassium peroxymonosulfate led to significant reduction in all tested Human adenovirus D types comparable to disinfecting effects by 0.1% NaClO. Overall, potassium peroxymonosulfate demonstrated sufficient inactivation of the major epidemic keratoconjunctivitis-causing Human adenovirus D to be considered for disinfection and prevention purposes in ophthalmological clinics and hospitals. Conclusion: This study demonstrated that potassium peroxymonosulfate is a promising disinfectant for the prevention of epidemic keratoconjunctivitis nosocomial infections in ophthalmological clinics.

Journal

• European journal of ophthalmology

  European journal of ophthalmology 31 (2), 379-384, 2021-03

  SAGE Publications

Keywords

• Human adenovirus
• epidemic keratoconjunctivitis
• disinfectants
• prevention
• RUBYSTA
• Virkon

Details

• CRID: 1050006895483816960
• NII Article ID: 120007044525
• HANDLE: 2115/81697
• ISSN: 11206721
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • CiNii Articles