Successful treatment with recombinant thrombomodulin for B-cell lymphoma-associated hemophagocytic syndrome complicated by disseminated intravascular coagulation

• Uni Masahiro

• Yoshimi Akihide

• Maki Hiroaki

• Maeda Daichi

• Nakazaki Kumi

• Nakamura Fumihiko

• Fukayama Masashi

• Kurokawa Mineo

• 前田 大地

抄録

金沢大学医薬保健研究域医学系

We report here a 47-year-old male with the diagnosis of high-grade B-cell lymphoma and hemophagocytosis accompanying disseminated intravascular coagulation (DIC). Lymphoma-associated hemophagocytic syndrome (LAHS) is a life-threatening disorder, and LAHS secondary to B-cell lymphoma is relatively rare compared to that secondary to T- or NK/T-cell lymphoma in Western countries. T- or NK/T-cell LAHS is sometimes combined with DIC, which makes patients' outcomes even worse, but few reports of B-cell LAHS accompanying DIC has been published so far. We successfully treated a patient with this condition with recombinant thrombomodulin (rTM), a novel agent for DIC. We believe that rTM is a therapeutic option in cases with B-cell LAHS accompanying DIC.

収録刊行物

• International Journal of Clinical and Experimental Pathology

  International Journal of Clinical and Experimental Pathology 6 (6), 1190-1194, 2013-05-15

  e-Century Publishing

キーワード

• B-cell lymphoma
• disseminated intravascular coagulation
• lymphoma-associated hemophagocytic syndrome
• recombinant thrombomodulin

詳細情報

• CRID: 1390290700499772032
• NII論文ID: 120007089059
• DOI: 10.24517/00062691
• ISSN: 19362625
• Web Site: http://hdl.handle.net/2297/00062691
• 本文言語コード: en
• データソース種別:
  • JaLC
  • IRDB
  • CiNii Articles