Association of cognitive performance with interleukin-6 receptor Asp358Ala polymorphism in healthy adults

• Sasayama, Daimei

• Hori, Hiroaki

• Teraishi, Toshiya

• Hattori, Kotaro

• Ota, Miho

• Matsuo, Junko

• Kawamoto, Yumiko

• Kinoshita, Yukiko

• Amano, Naoji

• Kunugi, Hiroshi

抄録

Wechsler adult intelligence scale-revised was performed in 576 healthy adults to examine whether a functional polymorphism (Asp358Ala) of the IL-6 receptor (IL-6R) gene is associated with cognitive performance. Verbal intelligence quotient in Asp homozygotes was significantly higher compared to Ala carriers (P = 0.005). Compared to Ala carriers, Asp homozygotes performed better in the verbal subtests requiring long-term memory stores. Elevated IL-6 and soluble IL-6R levels in Ala carriers may have negative impact on acquiring verbal cognitive ability requiring long-term memory.

Article

JOURNAL OF NEURAL TRANSMISSION. 119(3):313-318 (2012)

収録刊行物

• JOURNAL OF NEURAL TRANSMISSION

  JOURNAL OF NEURAL TRANSMISSION 119 (3), 313-318, 2012-03

  SPRINGER WIEN

キーワード

• Cognitive function
• Interleukin-6
• Genetic polymorphism
• Intelligence

詳細情報

• CRID: 1050845763844306944
• NII論文ID: 120007110620
• NII書誌ID: AA11077137
• HANDLE: 10091/17722
• ISSN: 03009564
• Web Site: https://soar-ir.repo.nii.ac.jp/records/3693
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles