Superiority of CRP-albumin-lymphocyte index (CALLY index) as a non-invasive prognostic biomarker after hepatectomy for hepatocellular carcinoma.

• IIDA, Hiroya

• TANI, Masaji

• KOMEDA, Koji

• NOMI, Takeo

• MATSUSHIMA, Hideyuki

• TANAKA, Shogo

• UENO, Masaki

• NAKAI, Takuya

• MAEHIRA, Hiromitsu

• MORI, Haruki

• MATSUI, Kosuke

• HIROKAWA, Fumitoshi

• KAIBORI, Masaki

• KUBO, Shoji

• 飯田, 洋也

• 谷, 眞至

• 前平, 博充

• 森, 治樹

抄録

type:Journal Article

Background:We aimed to investigate whether a novel biomarker incorporating albumin, lymphocytes, and CRP can predict the prognosis for hepatocellular carcinoma (HCC) after hepatectomy.

Methods:Between January 2011 and December 2013, 384 patients who underwent hepatectomy in four university hospitals in Japan were investigated as a discovery cohort. The CRP-Albumin-Lymphocyte (CALLY index) was defined as (Albumin × Lymphocyte)/(CRP × 104). Patients with a CALLY index ≥5 (n = 200) were compared to those with an index <5 (n = 184). Next, validation was performed using 267 patients from three other university hospitals (external validation cohort).

Results:The number of TNM Stage III and IV patients was significantly higher in the CALLY <5 group than the ≥5 group (p = 0.003). There was a significant difference in the 5-year survival rate (CALLY ≥5: 71% vs. <5: 46%; p < 0.001). Multivariate analysis identified the CALLY index as an independent factor of overall survival. Similarly, there was a significant difference in the 5-year survival rate between the CALLY ≥5 (73%) and <5 (48%) groups (p < 0.001), and the CALLY index was identified as an independent prognostic factor in the external validation cohort.

Conclusion:The CALLY index derived from CRP, albumin, and lymphocyte values is a promising predictive biomarker for postoperative prognosis of patients with HCC.

収録刊行物

• HPB : the official journal of the International Hepato Pancreato Biliary Association

  HPB : the official journal of the International Hepato Pancreato Biliary Association 2021-06-22

  Elsevier B.V.

キーワード

• Hepatocellular Carcinoma
• Non-invasive prognostic biomarker
• Hepatectomy
• CALLY index

詳細情報

• CRID: 1050570264726002816
• NII論文ID: 120007123987
• ISSN: 14772574
• Web Site: http://hdl.handle.net/10422/00013048
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
  • IRDB
  • CiNii Articles