Vagus Nerve Stimulation with Mild Stimulation Intensity Exerts Anti-Inflammatory and Neuroprotective Effects in Parkinson's Disease Model Rats

• Kin, Ittetsu

• Sasaki, Tatsuya

• Yasuhara, Takao

• Kameda, Masahiro

• Agari, Takashi

• Okazaki, Mihoko

• Hosomoto, Kakeru

• Okazaki, Yosuke

• Yabuno, Satoru

• Kawauchi, Satoshi

• Kuwahara, Ken

• Morimoto, Jun

• Kin, Kyohei

• Umakoshi, Michiari

• Tomita, Yousuke

• Tajiri, Naoki

• Borlongan, Cesario, V

• Date, Isao

Abstract

Background: The major surgical treatment for Parkinson's disease (PD) is deep brain stimulation (DBS), but a less invasive treatment is desired. Vagus nerve stimulation (VNS) is a relatively safe treatment without cerebral invasiveness. In this study, we developed a wireless controllable electrical stimulator to examine the efficacy of VNS on PD model rats. Methods: Adult female Sprague-Dawley rats underwent placement of a cuff-type electrode and stimulator on the vagus nerve. Following which, 6-hydroxydopamine (6-OHDA) was administered into the left striatum to prepare a PD model. VNS was started immediately after 6-OHDA administration and continued for 14 days. We evaluated the therapeutic effects of VNS with behavioral and immunohistochemical outcome assays under different stimulation intensity (0.1, 0.25, 0.5 and 1 mA). Results: VNS with 0.25-0.5 mA intensity remarkably improved behavioral impairment, preserved dopamine neurons, reduced inflammatory glial cells, and increased noradrenergic neurons. On the other hand, VNS with 0.1 mA and 1 mA intensity did not display significant therapeutic efficacy. Conclusions: VNS with 0.25-0.5 mA intensity has anti-inflammatory and neuroprotective effects on PD model rats induced by 6-OHDA administration. In addition, we were able to confirm the practicality and effectiveness of the new experimental device.

Journal

• Biomedicines

  Biomedicines 9 (7), 789-, 2021-07-07

  MDPI

Keywords

• anti-inflammation
• less invasive therapy
• new experimental device
• Parkinson's disease
• vagus nerve stimulation

Details

• CRID: 1050007515079364096
• NII Article ID: 120007126501
• ISSN: 22279059
• DOI: 10.3390/biomedicines9070789
• Web Site: https://ousar.lib.okayama-u.ac.jp/62302
• Web Site: https://www.mdpi.com/2227-9059/9/7/789/pdf
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN