An Unprecedented Case of p190 BCR-ABL Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature
Bibliographic Information
- Other Title
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- An Unprecedented Case of p190 <i>BCR-ABL</i> Chronic Myeloid Leukemia Diagnosed during Treatment for Multiple Myeloma: A Case Report and Review of the Literature
Abstract
<jats:p>We report the case of a 76-year-old man who was diagnosed as having chronic myeloid leukemia (CML) with p190 <jats:italic>BCR-ABL</jats:italic> while receiving treatment for symptomatic multiple myeloma (MM). The diagnosis of MM was based on the presence of serum M-protein, abnormal plasma cells in the bone marrow, and lytic bone lesions. The patient achieved a partial response to lenalidomide and dexamethasone treatment. However, 2 years after the diagnosis of MM, the patient developed leukocytosis with granulocytosis, anemia, and thrombocytopenia. Bone marrow examination revealed Philadelphia chromosomes and chimeric p190 <jats:italic>BCR-ABL</jats:italic> mRNA. Fluorescence in situ hybridization also revealed <jats:italic>BCR-ABL</jats:italic>-positive neutrophils in the peripheral blood, which suggested the emergence of CML with p190 <jats:italic>BCR-ABL</jats:italic>. The codevelopment of MM and CML is very rare, and this is the first report describing p190 <jats:italic>BCR-ABL</jats:italic>-type CML coexisting with MM. Moreover, we have reviewed the literature regarding the coexistence of these diseases.</jats:p>
Journal
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- Case Reports in Hematology
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Case Reports in Hematology 2018 7863943-, 2018-10
Hindawi Publishing Corporation
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Keywords
Details 詳細情報について
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- CRID
- 1050282677532614784
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- NII Article ID
- 120007128268
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- ISSN
- 20906579
- 20906560
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- HANDLE
- 2241/00154818
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- Text Lang
- en
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- Article Type
- journal article
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- Data Source
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- IRDB
- Crossref
- CiNii Articles
- KAKEN