Evolutionary dynamics of spliceosomal intron revealed by in silico analyses of the P-Type ATPase superfamily genes
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抄録
It has been long debated whether spliceosomal introns originated in the common ancestor of eukaryotes and prokaryotes. In this study, we tested the possibility that extant introns were inherited from the common ancestor of eukaryotes and prokaryotes using in silico simulation. We first identified 21 intron positions that are shared among different families of the P-Type ATPase superfamily, some of which are known to have diverged before the separation of prokaryotes and eukaryotes. Theoretical estimates of the expected number of intron positions shared by different genes suggest that the introns at those 21 positions were inserted independently. There seems to be no intron that arose from before the diversification of the P-Type ATPase superfamily. Namely, the present introns were inserted after the separation of eukaryotes and prokaryotes.
収録刊行物
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- Molecular biology reports
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Molecular biology reports 38 (4), 2285-2293, 2011-04
Springer
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キーワード
- Spliceosomal intron
- Introns-late theory
- Introns-early theory
- Simulation
- Proto-splice site
- P-Type ATPase
- Amino Acid Sequence
- Animals
- Evolution, Molecular
- Gene Components
- Humans
- Inheritance Patterns/genetics
- Introns/genetics
- Molecular Sequence Data
- Multigene Family/genetics
- Proton-Translocating ATPases/genetics
- Sequence Alignment
- Species Specificity
- Spliceosomes/genetics
詳細情報 詳細情報について
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- CRID
- 1050001202624473600
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- NII論文ID
- 120007130900
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- NII書誌ID
- AA00745797
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- ISSN
- 15734978
- 03014851
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- HANDLE
- 2241/113268
- 2433/147052
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- 本文言語コード
- en
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- 資料種別
- journal article
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- データソース種別
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- IRDB
- Crossref
- CiNii Articles
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