Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinitis with nasal polyps

DOI IR HANDLE PDF Web Site 18 Citations 54 References Open Access

Bibliographic Information

Other Title
  • Periostin as a novel biomarker for postoperative recurrence of chronic rhinosinusitis with nasal polyps

Abstract

<jats:title>Abstract</jats:title><jats:p>We previously reported that chronic rhinosinusitis with nasal polyps (CRSwNP) was subdivided into four chronic rhinosinusitis (CRS) subtypes using the JESREC scoring system. We sought to identify the gene expression profile and biomarkers related with CRSwNP by RNA-sequence. RNA-sequencing was performed to identify differentially expressed genes between nasal polyps (NPs) and inferior turbinate mucosa from 6 patients with CRSwNP, and subsequently, quantitative real-time PCR was performed to verify the results. ELISA was performed to identify possible biomarkers for postoperative recurrence. In the RNA-sequencing results, <jats:italic>periostin</jats:italic> (<jats:italic>POSTN</jats:italic>) expression was the highest in NP. We focused on <jats:italic>POSTN</jats:italic> and investigated the protein level of POSTN by immunohistochemistry and ELISA. POSTN was diffusely expressed in moderate and severe eosinophilic CRS using immunohistochemistry, and its staining pattern was associated with the severity of the phenotype of the CRSwNP (<jats:italic>P</jats:italic> < 0.05). There was a significant difference between the POSTN high/low groups for postoperative recurrence when the cutoff point was set at 115.5 ng/ml (<jats:italic>P</jats:italic> = 0.0072). Our data suggests that the protein expression level of POSTN was associated with the severity of CRSwNP, and serum POSTN can be a novel biomarker for postoperative recurrence of CRSwNP.</jats:p>

Journal

Citations (18)*help

See more

References(54)*help

See more

Related Projects

See more

Keywords

Details 詳細情報について

Report a problem

Back to top