Long-term accumulation of diphenylarsinic acid in the central nervous system of cynomolgus monkeys

• 増田, 知之

• 石井, 一弘

• 田中, 竜太

• 玉岡, 晃

• Masuda, Tomoyuki

• Ishii, Kazuhiro

• Seto, Yasuo

• Hosoya, Tomoko

• Tanaka, Ryuta

• Nakayama, Tomohiro

• Iwasaki, Nobuaki

• Shibata, Yasuyuki

• Tamaoka, Akira

抄録

Diphenylarsinic acid (DPAA) is an organic arsenic compound used for the synthesis of chemical weapons. We previously found that the residents of Kamisu city in Ibaraki Prefecture, Japan, were exposed to DPAA through contaminated well water in 2003. Although mounting evidence strongly suggests that their neurological symptoms were caused by DPAA, the dynamics of DPAA distribution and metabolism after ingestion by humans remain to be elucidated. To accurately predict the distribution of DPAA in the human body, we administrated DPAA (1.0 mg/kg/day) to cynomolgus monkeys (n = 28) for 28 days. The whole tissues from these monkeys were collected at 5, 29, 170, and 339 days after the last administration. The concentration of DPAA in these tissues was measured by liquid chromatography–mass spectrometry. We found that DPAA accumulated in the central nervous system tissues for a longer period than in other tissues. This finding would extend our knowledge on the distribution dynamics and metabolism of DPAA in primates, including humans. Furthermore, it may be useful for developing a treatment strategy for patients who are exposed to DPAA.

収録刊行物

• Archives of toxicology

  Archives of toxicology 91 (8), 2799-2812, 2017-01

  Springer International Publishing AG.

キーワード

• Health, Toxicology and Mutagenesis
• Toxicology
• General Medicine

詳細情報

• CRID: 1050282677537399424
• NII論文ID: 120007134636
• NII書誌ID: AA00548865
• ISSN: 03405761
• ISSN: 14320738
• DOI: 10.1007/s00204-016-1928-z
• HANDLE: 2241/00150612
• Web Site: https://tsukuba.repo.nii.ac.jp/records/45336
• Web Site: http://link.springer.com/article/10.1007/s00204-016-1928-z/fulltext.html
• Web Site: http://link.springer.com/content/pdf/10.1007/s00204-016-1928-z.pdf
• 本文言語コード: en
• 資料種別: journal article
• データソース種別:
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