Secretory Carcinoma of Salivary Gland with High-Grade Histology Arising in Hard Palate: A Case Report

• Takabatake, Kiyofumi

• Nakano, Keisuke

• Kawai, Hotaka

• Yoshida, Saori

• Omori, Haruka

• Oo, May Wathone

• Qiusheng, Shan

• Uchida, Kenichiro

• Mishima, Katsuaki

• Nagatsuka, Hitoshi

Abstract

Secretory carcinoma (SC) is a recently described salivary gland tumor reported in the fourth edition of World Health Organization classification of head and neck tumors. SC is characterized by strong S-100 protein, mammaglobin, and vimentin immunoexpression, and harbors a t(12;15)(p13;q25) translocation which leads to ETV6-NTRK3 fusion product. Histologically, SC displays a lobulated growth pattern and is often composed of microcystic, tubular, and solid structures with abundant eosinophilic homogenous or bubbly secretion. SC is generally recognized as low-grade malignancy with low-grade histopathologic features, and metastasis is relatively uncommon. In this case, we described a SC of hard palate that underwent high grade transformation and metastasis to the cervical lymph node in a 54-year-old patient. In addition, this case showed different histological findings between primary lesion and metastasis lesion. Therefore, the diagnosis was confirmed by the presence of ETV6 translocation. Here, we report a case that occurred SC with high-grade transformation in the palate, and a review of the relevant literature is also presented.

Journal

• reports

  reports 3 (2), 6-, 2020-03-25

  MDPI

Keywords

• secretory carcinoma
• high-grade transformation
• ETV6-NTRK3 fusion
• cervical lymph node metastasis

Details

• CRID: 1050570620384224128
• NII Article ID: 120007139733
• ISSN: 2571841X
• DOI: 10.3390/reports3020006
• Web Site: https://ousar.lib.okayama-u.ac.jp/62326
• Web Site: https://www.mdpi.com/2571-841X/3/2/6/pdf
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN