Development of a mugineic acid family phytosiderophore analog as an iron fertilizer

• Suzuki, Motofumi

• Urabe, Atsumi

• Sasaki, Sayaka

• Tsugawa, Ryo

• Nishio, Satoshi

• Mukaiyama, Haruka

• Murata, Yoshiko

• Masuda, Hiroshi

• Aung, May Sann

• Mera, Akane

• Takeuchi, Masaki

• Fukushima, Keijo

• Kanaki, Michika

• Kobayashi, Kaori

• Chiba, Yuichi

• Shrestha, Binod Babu

• Nakanishi, Hiromi

• Watanabe, Takehiro

• Nakayama, Atsushi

• Fujino, Hiromichi

• Kobayashi, Takanori

• Tanino, Keiji

• Nishizawa, Naoko K.

• Namba, Kosuke

Abstract

Iron (Fe) is an essential nutrient, but is poorly bioavailable because of its low solubility in alkaline soils; this leads to reduced agricultural productivity. To overcome this problem, we first showed that the soil application of synthetic 2′-deoxymugineic acid, a natural phytosiderophore from the Poaceae, can recover Fe deficiency in rice grown in calcareous soil. However, the high cost and poor stability of synthetic 2′-deoxymugineic acid preclude its agricultural use. In this work, we develop a more stable and less expensive analog, proline-2′-deoxymugineic acid, and demonstrate its practical synthesis and transport of its Fe-chelated form across the plasma membrane by Fe(III)•2’-deoxymugineic acid transporters. Possibility of its use as an iron fertilizer on alkaline soils is supported by promotion of rice growth in a calcareous soil by soil application of metal free proline-2’-deoxymugineic acid.

Journal

• Nature Communications

  Nature Communications 12 1558-, 2021-03-10

  Springer Nature

Keywords

• General Physics and Astronomy
• General Biochemistry, Genetics and Molecular Biology
• General Chemistry
• Multidisciplinary

Details

• CRID: 1050852174950955136
• NII Article ID: 120007141554
• NII Book ID: AA12645905
• ISSN: 20411723
• DOI: 10.1038/s41467-021-21837-6
• Web Site: http://repo.lib.tokushima-u.ac.jp/116178
• Web Site: https://www.nature.com/articles/s41467-021-21837-6.pdf
• Web Site: https://www.nature.com/articles/s41467-021-21837-6
• Text Lang: en
• Article Type: journal article
• Data Source:
  • IRDB
  • Crossref
  • CiNii Articles
  • KAKEN